Registration of securities issued in business combination transactions

Commitments and Contingencies - Additional Information (Detail)

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Commitments and Contingencies - Additional Information (Detail)
1 Months Ended 3 Months Ended 4 Months Ended 12 Months Ended
Aug. 01, 2015
ft²
Apr. 24, 2015
USD ($)
Aug. 31, 2016
USD ($)
Feb. 28, 2015
USD ($)
ft²
Dec. 31, 2009
USD ($)
Mar. 31, 2017
USD ($)
Mar. 31, 2016
USD ($)
Apr. 24, 2015
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Mar. 31, 2017
CAD
Dec. 31, 2016
CAD
Sep. 30, 2016
USD ($)
May 14, 2015
Feb. 01, 2015
USD ($)
Other Commitments [Line Items]                                
Expiration of operating lease agreement           2017-09     2017-09              
Additional office space | ft² 2,245                              
Consolidated rent and facilities expense           $ 100,000 $ 100,000   $ 600,000 $ 900,000 $ 2,800,000          
Lease termination agreement, additional fee payable       $ 1,300,000                        
Indemnification obligations           0     0              
Expenses related to indemnification issues           0     0              
Gross proceeds                     $ 22,372,000          
CANADA                                
Other Commitments [Line Items]                                
Aggregate future minimum annual lease payments under the lease           46,000,000     68,000,000              
Ionis Pharmaceuticals Inc. [Member]                                
Other Commitments [Line Items]                                
Litigation settlement, upfront payment     $ 1,400,000                          
Royalty payment percentage     5.00%                          
Sale, license or other transaction payment percentage     50.00%                          
Ionis Pharmaceuticals Inc. [Member] | Maximum [Member]                                
Other Commitments [Line Items]                                
Litigation settlement, success based payment     $ 5,000,000                          
Grosvenor International Limited [Member]                                
Other Commitments [Line Items]                                
Area of office space leased | ft²       11,526                        
Expiration date of option to lease additional area of office space       Aug. 01, 2015                        
Lease expiration date       Apr. 30, 2018                        
Optional lease renewal       3 years                        
Monthly base rent commencement date       May 01, 2015                        
Lessee's share of property tax percentage.       17.00%                        
Construction allowance received for leasehold improvements                               $ 100,000
Deposit amount under lease agreement                               $ 200,000
Grosvenor International Limited [Member] | Maximum [Member]                                
Other Commitments [Line Items]                                
Monthly base rent       $ 20,000                        
Grosvenor International Limited [Member] | Minimum [Member]                                
Other Commitments [Line Items]                                
Monthly base rent       $ 18,000                        
BMR-217TH Place LLC [Member]                                
Other Commitments [Line Items]                                
Lease expiration date       Mar. 01, 2015                        
Lease termination agreement, date of termination       Mar. 01, 2015                        
Letter of credit drawn to pay deferred state sales tax       $ 100,000                        
Letter of credit terminated       200,000                        
Terminated lease       500,000                        
Reversed lease termination liability current                           $ 1,300,000    
BMR-217TH Place LLC [Member] | Termination Fee [Member]                                
Other Commitments [Line Items]                                
Lease termination agreement, fee payable       2,000,000                        
BMR-217TH Place LLC [Member] | Minimum [Member]                                
Other Commitments [Line Items]                                
Amount of funding to raise that would trigger payment of additional termination fee       $ 20,000,000                        
Collaborative Arrangement [Member] | Teva Pharmaceutical Industries Ltd. [Member]                                
Other Commitments [Line Items]                                
Proceeds from advance reimbursement research and development               $ 27,000,000                
Hold-back amount and third-party expenses deducted from advanced reimbursement payment   $ 3,800,000           3,800,000                
Hold-back amount deducted from advanced reimbursement payment   3,000,000           3,000,000                
Third-party expenses deducted from advanced reimbursement payment               $ 800,000                
Maximum cost exposure if third-party agreements discovered after the termination date           $ 100,000     100,000              
Collaboration agreement aggregate amount         $ 50,000,000                      
Gross proceeds                 10,000,000              
Direct and indirect costs incurred                 $ 30,000,000              
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member]                                
Other Commitments [Line Items]                                
Collaboration agreement aggregate amount   $ 23,200,000                            
Hold-back amount, requested payment percentage                             30.00%  
Lawsuit filing date           January 2016     January 2016              
Range of each product line           10 years     10 years              
Net proceed from collaboration agreement amount, requested payment percentage                             20.00%  
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member] | Maximum [Member]                                
Other Commitments [Line Items]                                
Milestone payments           $ 4,300,000     $ 7,750,000              
Collaborative Arrangement [Member] | University of British Columbia [Member] | Maximum [Member]                                
Other Commitments [Line Items]                                
Milestone payments | CAD                       CAD 800,000 CAD 1,600,000      
Payments for royalty           $ 0