Consolidated Statements of Loss and Comprehensive Loss - USD ($) $ in Thousands |
3 Months Ended | 12 Months Ended | |||
|---|---|---|---|---|---|
Mar. 31, 2017 |
Mar. 31, 2016 |
Dec. 31, 2016 |
Dec. 31, 2015 |
Dec. 31, 2014 |
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| Statement of Comprehensive Income [Abstract] | |||||
| Collaboration revenue | $ 2,940 | $ 5,062 | $ 18,160 | $ 27,116 | |
| EXPENSES | |||||
| Research and development | $ 912 | 4,642 | 14,788 | 25,108 | 46,224 |
| General and administrative | 2,532 | 2,299 | 8,933 | 11,805 | 10,625 |
| Restructuring costs (recovery) | (98) | 431 | 2,206 | (267) | |
| Recovery of lease termination loss | (1,250) | ||||
| Litigation settlement | 1,375 | ||||
| Asset impairment charge | 202 | ||||
| Total operating expenses | 3,346 | 7,372 | 26,254 | 36,913 | 56,582 |
| OTHER INCOME (EXPENSE) | |||||
| Interest income | 27 | 48 | 203 | 119 | 35 |
| Other | (2) | 10 | (13) | (64) | (19) |
| Warrant issuance costs | (531) | ||||
| Gain on warrants | 52 | 667 | 873 | 1,897 | 3,741 |
| Total other income | 77 | 725 | 1,063 | 1,952 | 3,226 |
| Net loss | (3,269) | (3,707) | (20,129) | (16,801) | (26,240) |
| OTHER COMPREHENSIVE INCOME | |||||
| Net unrealized gain (loss) on securities | 1 | 14 | 8 | 10 | (21) |
| Total other comprehensive income | 1 | 14 | 8 | 10 | (21) |
| Comprehensive loss | $ (3,268) | $ (3,693) | $ (20,121) | $ (16,791) | $ (26,261) |
| Basic and diluted net loss per common share | $ (0.11) | $ (0.12) | $ (0.67) | $ (0.64) | $ (1.45) |
| Shares used in computation of basic and diluted net loss per common share | 30,076,160 | 29,827,824 | 29,949,432 | 26,147,344 | 18,098,799 |
| X | ||||||||||
- Definition Gain (loss) related to reversal of lease termination liability of a contract between the parties. No definition available.
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- Definition Restructuring costs (recovery). No definition available.
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- Definition Warrant issuance costs. No definition available.
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- Definition Amount of write-down of assets recognized in the income statement. Includes, but is not limited to, losses from tangible assets, intangible assets and goodwill. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition Total costs of sales and operating expenses for the period. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- References No definition available.
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- Definition The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. No definition available.
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- Definition Amount of expense (income) related to adjustment to fair value of warrant liability. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition Amount before accretion (amortization) of purchase discount (premium) of interest income on nonoperating securities. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition Amount of litigation expense, including but not limited to legal, forensic, accounting, and investigative fees. No definition available.
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- Definition The portion of profit or loss for the period, net of income taxes, which is attributable to the parent. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition The aggregate amount of income or expense from ancillary business-related activities (that is to say, excluding major activities considered part of the normal operations of the business). Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- References No definition available.
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- Definition Amount after tax and reclassification adjustments of other comprehensive income (loss). Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- References No definition available.
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- Definition Amount after tax, before reclassification adjustments, of unrealized holding gain (loss) on available-for-sale securities. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition Amount of income (expense) related to nonoperating activities, classified as other. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition Repayment received or receivable for expenses incurred on behalf of a client or customer, other than those reimbursements received by landlords from tenants. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. Reference 1: http://www.xbrl.org/2003/role/presentationRef
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- References No definition available.
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- Definition Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS). No definition available.
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