Registration of securities issued in business combination transactions

Consolidated Statements of Cash Flows

v3.7.0.1
Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating Activities:          
Net loss $ (3,269) $ (3,707) $ (20,129) $ (16,801) $ (26,240)
Adjustments to reconcile net loss to net cash used in operating activities:          
Gain on warrants (52) (667) (873) (1,897) (3,741)
Warrant issuance costs         531
Depreciation 93 56 188 244 223
Asset impairment charge     202    
Stock-based compensation 211 468 1,649 2,328 3,860
Restructuring gain (98)       (3,517)
Changes in operating assets and liabilities:          
Interest receivable 32 58 79 2 105
Amounts receivable 241 (219) (464) 5,662 2,981
Prepaid expenses and other assets 189 401 1,057 1,167 3,944
Accounts payable (1,762) (751) 778 1,271 (67)
Accrued liabilities other (1,510) 268 1,801 (222) 363
Accrued clinical liabilities (3,073) (1,516) (6,551) (3,714) 2,178
Accrued compensation 22 (523) (1,079) (66) (372)
Restricted cash       (21) 63
Excess lease liability       (194) (785)
Lease obligation (19) (14) (51) 100 (84)
Lease termination fees     (1,250) (2,000) 3,250
Deferred collaboration revenue   (2,941) (5,040) 5,040  
Net cash used in operating activities (8,995) (9,087) (29,683) (9,101) (17,308)
Financing Activities:          
Proceeds from the exercise of stock options       14 30
Taxes paid related to net share settlement of equity awards (19)   (2) (52) (29)
Issuance of common shares, net of share issuance costs         22,372
Net cash provided by (used in) financing activities (19)   (2) 17,591 25,247
Investing Activities:          
Purchase of investments (5) (24,169) (36,504) (24,368) (19,446)
Proceeds from sale of investments       1,003  
Proceeds from maturities of investments 9,475 17,859 47,158 21,659 24,894
Purchase of property and equipment (1)   (46) (371) (82)
Net cash provided by (used in) investing activities 9,469 (6,310) 10,608 (2,077) 5,366
Effect of exchange rate changes on cash 2       (1)
Net increase (decrease) in cash and cash equivalents 457 (15,397) (19,077) 6,413 13,304
Cash and cash equivalents at beginning of period 15,233 34,310 34,310 27,897 14,593
Cash and cash equivalents at end of period $ 15,690 $ 18,913 $ 15,233 34,310 27,897
Supplemental Disclosure of Cash Flow Information:          
Property and equipment received and accrued but not yet paid       218  
ATM Financing [Member]          
Financing Activities:          
Proceeds from ATM Financing, net of issuance costs       $ 17,629 $ 2,874