Quarterly report pursuant to Section 13 or 15(d)

Subsequent Events - Additional Information (Detail)

v3.5.0.2
Subsequent Events - Additional Information (Detail) - Subsequent Event [Member] - Ionis Pharmaceuticals Inc. [Member]
$ in Millions
Aug. 01, 2016
USD ($)
Subsequent Event [Line Items]  
Litigation settlement, upfront payment $ 1.4
Royalty payment percentage 5.00%
Sale, license or other transaction payment percentage 50.00%
Maximum [Member]  
Subsequent Event [Line Items]  
Litigation settlement, success based payment $ 5.0
Sale, license or other transaction payment percentage 50.00%