Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Detail)

v3.5.0.2
Commitments and Contingencies - Additional Information (Detail)
1 Months Ended 3 Months Ended 4 Months Ended 6 Months Ended
Aug. 01, 2016
USD ($)
Aug. 01, 2015
ft²
Apr. 24, 2015
USD ($)
Feb. 29, 2016
USD ($)
Employee
Feb. 28, 2015
USD ($)
ft²
Dec. 31, 2009
USD ($)
Jun. 30, 2016
USD ($)
Jun. 30, 2015
USD ($)
Apr. 24, 2015
USD ($)
Jun. 30, 2016
USD ($)
Jun. 30, 2015
USD ($)
Jun. 30, 2016
CAD
Dec. 31, 2015
USD ($)
May 14, 2015
Feb. 01, 2015
USD ($)
Other Commitments [Line Items]                              
Expiration of operating lease agreement                   2016-09          
Additional office space | ft²   2,245                          
Consolidated rent and facilities expense             $ 100,000 $ 100,000   $ 300,000 $ 700,000        
Lease termination agreement, additional fee payable         $ 1,300,000                    
Lease termination liability             1,250,000     1,250,000     $ 1,250,000    
Indemnification obligations             0     0          
Expenses related to indemnification issues                   0          
Reduction in workforce | Employee       11                      
Percentage of workforce reduction       27.00%                      
Expenses on workforce reduction       $ 400,000                      
Vancouver, Canada [Member]                              
Other Commitments [Line Items]                              
Aggregate future minimum annual lease payments under the lease             100,000     100,000          
Ionis Pharmaceuticals Inc. [Member] | Subsequent Event [Member]                              
Other Commitments [Line Items]                              
Litigation settlement, upfront payment $ 1,400,000                            
Royalty payment percentage 5.00%                            
Sale, license or other transaction payment percentage 50.00%                            
Ionis Pharmaceuticals Inc. [Member] | Maximum [Member] | Subsequent Event [Member]                              
Other Commitments [Line Items]                              
Litigation settlement, success based payment $ 5,000,000                            
Sale, license or other transaction payment percentage 50.00%                            
Grosvenor International Limited [Member]                              
Other Commitments [Line Items]                              
Area of office space leased | ft²         11,526                    
Expiration date of option to lease additional area of office space         Aug. 01, 2015                    
Lease expiration date         Apr. 30, 2018                    
Optional lease renewal         3 years                    
Monthly base rent commencement date         May 01, 2015                    
Lessee's share of property tax percentage.         17.00%                    
Construction allowance received for leasehold improvements                             $ 100,000
Deposit amount under lease agreement                             $ 200,000
Grosvenor International Limited [Member] | Maximum [Member]                              
Other Commitments [Line Items]                              
Monthly base rent         $ 20,000                    
Grosvenor International Limited [Member] | Minimum [Member]                              
Other Commitments [Line Items]                              
Monthly base rent         $ 18,000                    
BMR-217TH Place LLC [Member]                              
Other Commitments [Line Items]                              
Lease termination agreement, date of termination         Mar. 01, 2015                    
Letter of credit drawn to pay deferred state sales tax         $ 100,000                    
Letter of credit terminated         200,000                    
Terminated lease         500,000                    
Lease termination liability             1,300,000     1,300,000          
BMR-217TH Place LLC [Member] | Termination Fee [Member]                              
Other Commitments [Line Items]                              
Lease termination agreement, fee payable         2,000,000                    
BMR-217TH Place LLC [Member] | Minimum [Member]                              
Other Commitments [Line Items]                              
Amount of funding to raise that would trigger payment of additional termination fee         $ 20,000,000                    
Collaborative Arrangement [Member] | Teva Pharmaceutical Industries Ltd. [Member]                              
Other Commitments [Line Items]                              
Proceeds from advance reimbursement research and development                 $ 27,000,000            
Hold-back amount and third-party expenses deducted from advanced reimbursement payment     $ 3,800,000           3,800,000            
Hold-back amount deducted from advanced reimbursement payment     3,000,000           3,000,000            
Third-party expenses deducted from advanced reimbursement payment                 $ 800,000            
Maximum cost exposure if third-party agreements discovered after the termination date                   100,000          
Collaboration agreement aggregate amount           $ 50,000,000                  
Gross proceeds                   10,000,000          
Direct and indirect costs incurred             30,000,000     $ 30,000,000          
Collaborative Arrangement [Member] | University of British Columbia [Member] | Maximum [Member]                              
Other Commitments [Line Items]                              
Milestone payments | CAD                       CAD 1,600,000      
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member]                              
Other Commitments [Line Items]                              
Collaboration agreement aggregate amount     $ 23,200,000                        
Net proceed from collaboration agreement amount, requested payment percentage                           20.00%  
Hold-back amount, requested payment percentage                           30.00%  
Lawsuit filing date                   January 5, 2016          
Range of each product line                   10 years          
Milestone payment due                   $ 20,000,000          
Period of milestone payment                   21 days          
Reserve for contingency of non payment of non-royalty milestone amount             20,000,000     $ 20,000,000          
Milestone payment made             10,000,000     10,000,000          
Balance amount of milestone payment             10,000,000     10,000,000          
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member] | Maximum [Member]                              
Other Commitments [Line Items]                              
Milestone payments             $ 7,750,000     $ 7,750,000