Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Detail)

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Commitments and Contingencies - Additional Information (Detail)
1 Months Ended 3 Months Ended 4 Months Ended 6 Months Ended
Apr. 24, 2015
USD ($)
Feb. 28, 2015
USD ($)
ft²
Dec. 31, 2009
USD ($)
Jun. 30, 2015
USD ($)
Jun. 30, 2014
USD ($)
Apr. 24, 2015
USD ($)
Jun. 30, 2015
USD ($)
ft²
Jun. 30, 2015
CAD
ft²
Jun. 30, 2014
USD ($)
Jun. 30, 2015
CAD
May. 14, 2015
Feb. 01, 2015
USD ($)
Dec. 31, 2014
USD ($)
Other Commitments [Line Items]                          
Gross Proceeds                 $ 2,860,000        
Expiration of operating lease agreement             2015-09 2015-09          
Consolidated rent and facilities expense       $ 100,000 $ 700,000   $ 700,000   $ 1,400,000        
Lease termination agreement, additional fee payable   $ 1,300,000                      
Lease termination liability       1,250,000     1,250,000           $ 3,250,000
Indemnification obligations       0     0            
Expenses related to indemnification issues             $ 0            
Grosvenor International Limited [Member]                          
Other Commitments [Line Items]                          
Area of office space leased | ft²   11,526                      
Additional area of office space available to lease, optional | ft²   8,054                      
Expiration date of option to lease additional area of office space   Aug. 01, 2015                      
Lease expiration date   Apr. 30, 2018                      
Optional lease renewal   3 years                      
Monthly base rent commencement date   May 01, 2015                      
Lessee's share of property tax percentage.   17.00%                      
Lease agreement, construction allowance receivable                       $ 100,000  
Deposit amount under lease agreement                       $ 200,000  
Additional office space | ft²             2,245 2,245          
Grosvenor International Limited [Member] | Maximum [Member]                          
Other Commitments [Line Items]                          
Monthly base rent   $ 20,000                      
Grosvenor International Limited [Member] | Minimum [Member]                          
Other Commitments [Line Items]                          
Monthly base rent   $ 18,000                      
BMR-217TH Place LLC [Member]                          
Other Commitments [Line Items]                          
Lease termination agreement, date of termination   Mar. 01, 2015                      
Letter of credit drawn to pay deferred state sales tax   $ 100,000                      
Letter of credit terminated   200,000                      
Terminated lease   500,000                      
Lease termination liability       1,300,000     $ 1,300,000            
BMR-217TH Place LLC [Member] | Termination Fee [Member]                          
Other Commitments [Line Items]                          
Lease termination agreement, fee paid   2,000,000                      
BMR-217TH Place LLC [Member] | Minimum [Member]                          
Other Commitments [Line Items]                          
Amount of funding to raise that would trigger payment of additional termination fee   $ 20,000,000                      
Collaborative Arrangement | Teva Pharmaceutical Industries Ltd. [Member]                          
Other Commitments [Line Items]                          
Proceeds From Advance reimbursement research and development           $ 27,000,000              
Hold-back amount and third-party expenses deducted from termination payment $ 3,800,000         3,800,000              
Hold-back amount deducted from termination payment 3,000,000         3,000,000              
Third-party expenses deducted from termination payment           $ 800,000              
Maximum cost exposure if third-party agreements discovered after the termination date             100,000            
Collaboration agreement aggregate amount     $ 50,000,000                    
Gross Proceeds             10,000,000            
Direct and indirect costs incurred       30,000,000     $ 30,000,000            
Collaborative Arrangement | University of British Columbia [Member]                          
Other Commitments [Line Items]                          
Obligation to pay patent costs and annual license maintenance fees | CAD               CAD 8,000          
Milestone payment | CAD               CAD 100,000          
Expiry period of agreement of patented license             20 years 20 years          
Collaborative Arrangement | University of British Columbia [Member] | Maximum [Member]                          
Other Commitments [Line Items]                          
Milestone payments | CAD                   CAD 1,600,000      
Collaborative Arrangement | Isis Pharmaceuticals Inc. [Member]                          
Other Commitments [Line Items]                          
Collaboration agreement aggregate amount $ 23,200,000                        
Net proceed from collaboration agreement amount, requested payment percentage                     30.00%    
Hold-back amount, requested payment percentage                     30.00%    
Amount due to Isis for reimbursement for research and development activities       0     $ 0            
Milestone payment             $ 800,000            
Range of each product line             10 years 10 years          
Milestone payment due             $ 20,000,000            
Period of milestone payment             21 days 21 days          
Reserve for contingency of non payment of non-royalty milestone amount       20,000,000     $ 20,000,000            
Milestone payment made       10,000,000     10,000,000            
Balance amount of milestone payment       10,000,000     10,000,000            
Collaborative Arrangement | Isis Pharmaceuticals Inc. [Member] | Maximum [Member]                          
Other Commitments [Line Items]                          
Milestone payments       $ 7,750,000     $ 7,750,000