Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Detail)

v3.3.0.814
Commitments and Contingencies - Additional Information (Detail)
1 Months Ended 3 Months Ended 4 Months Ended 9 Months Ended
Aug. 01, 2015
ft²
Apr. 24, 2015
USD ($)
Feb. 28, 2015
USD ($)
ft²
Dec. 31, 2009
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2014
USD ($)
Apr. 24, 2015
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2015
CAD
Sep. 30, 2014
USD ($)
Sep. 30, 2015
CAD
May. 14, 2015
Feb. 01, 2015
USD ($)
Dec. 31, 2014
USD ($)
Other Commitments [Line Items]                            
Gross Proceeds                   $ 22,372,000        
Expiration of operating lease agreement               2016-09 2016-09          
Consolidated rent and facilities expense         $ 100,000 $ 700,000   $ 800,000   $ 2,100,000        
Lease termination agreement, additional fee payable     $ 1,300,000                      
Lease termination liability         1,250,000     1,250,000           $ 3,250,000
Indemnification obligations         0     0            
Expenses related to indemnification issues               0            
Grosvenor International Limited [Member]                            
Other Commitments [Line Items]                            
Area of office space leased | ft²     11,526                      
Additional area of office space available to lease, optional | ft²     8,054                      
Expiration date of option to lease additional area of office space     Aug. 01, 2015                      
Lease expiration date     Apr. 30, 2018                      
Optional lease renewal     3 years                      
Monthly base rent commencement date     May 01, 2015                      
Lessee's share of property tax percentage.     17.00%                      
Lease agreement, construction allowance receivable                         $ 100,000  
Deposit amount under lease agreement                         $ 200,000  
Additional office space | ft² 2,245                          
Grosvenor International Limited [Member] | Maximum [Member]                            
Other Commitments [Line Items]                            
Monthly base rent     $ 20,000                      
Grosvenor International Limited [Member] | Minimum [Member]                            
Other Commitments [Line Items]                            
Monthly base rent     $ 18,000                      
BMR-217TH Place LLC [Member]                            
Other Commitments [Line Items]                            
Lease termination agreement, date of termination     Mar. 01, 2015                      
Letter of credit drawn to pay deferred state sales tax     $ 100,000                      
Letter of credit terminated     200,000                      
Terminated lease     500,000                      
Lease termination liability         1,300,000     1,300,000            
BMR-217TH Place LLC [Member] | Termination Fee [Member]                            
Other Commitments [Line Items]                            
Lease termination agreement, fee paid     2,000,000                      
BMR-217TH Place LLC [Member] | Minimum [Member]                            
Other Commitments [Line Items]                            
Amount of funding to raise that would trigger payment of additional termination fee     $ 20,000,000                      
Collaborative Arrangement | Teva Pharmaceutical Industries Ltd. [Member]                            
Other Commitments [Line Items]                            
Proceeds from advance reimbursement research and development             $ 27,000,000              
Hold-back amount and third-party expenses deducted from termination payment   $ 3,800,000         3,800,000              
Hold-back amount deducted from termination payment   3,000,000         3,000,000              
Third-party expenses deducted from termination payment             $ 800,000              
Expected receivables from hold-back amount         3,000,000     3,000,000            
Maximum cost exposure if third-party agreements discovered after the termination date               100,000            
Collaboration agreement aggregate amount       $ 50,000,000                    
Gross Proceeds               10,000,000            
Direct and indirect costs incurred         30,000,000     $ 30,000,000            
Collaborative Arrangement | University of British Columbia [Member]                            
Other Commitments [Line Items]                            
Obligation to pay patent costs and annual license maintenance fees | CAD                 CAD 8,000          
Milestone payment | CAD                 CAD 100,000          
Expiry period of agreement of patented license               20 years 20 years          
Collaborative Arrangement | University of British Columbia [Member] | Maximum [Member]                            
Other Commitments [Line Items]                            
Milestone payments | CAD                     CAD 1,600,000      
Collaborative Arrangement | Isis Pharmaceuticals Inc. [Member]                            
Other Commitments [Line Items]                            
Collaboration agreement aggregate amount   $ 23,200,000                        
Net proceed from collaboration agreement amount, requested payment percentage                       30.00%    
Hold-back amount, requested payment percentage                       30.00%    
Amount due to Isis for reimbursement for research and development activities         0     $ 0            
Milestone payment               $ 800,000            
Range of each product line               10 years 10 years          
Milestone payment due               $ 20,000,000            
Period of milestone payment               21 days 21 days          
Reserve for contingency of non payment of non-royalty milestone amount         20,000,000     $ 20,000,000            
Milestone payment made         10,000,000     10,000,000            
Balance amount of milestone payment         10,000,000     10,000,000            
Collaborative Arrangement | Isis Pharmaceuticals Inc. [Member] | Maximum [Member]                            
Other Commitments [Line Items]                            
Milestone payments         $ 7,750,000     $ 7,750,000