Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Detail)

v2.4.0.8
Commitments and Contingencies - Additional Information (Detail)
0 Months Ended 3 Months Ended 9 Months Ended 9 Months Ended 1 Months Ended 9 Months Ended
Jul. 02, 2014
USD ($)
Sep. 30, 2014
USD ($)
Sep. 30, 2013
USD ($)
Sep. 30, 2014
USD ($)
Sep. 30, 2013
USD ($)
Sep. 30, 2014
Excess lease facility [Member]
USD ($)
Dec. 31, 2013
Excess lease facility [Member]
USD ($)
Sep. 30, 2014
Other Long Term Assets [Member]
USD ($)
Sep. 30, 2014
Isis Pharmaceuticals Inc. and University of British Columbia [Member]
USD ($)
Sep. 30, 2014
Isis Pharmaceuticals Inc. and University of British Columbia [Member]
Collaboration arrangement [Member]
CAD
Sep. 30, 2014
Isis Pharmaceuticals Inc. [Member]
Collaboration arrangement [Member]
USD ($)
Dec. 31, 2009
Teva Pharmaceutical Industries Ltd. [Member]
Collaboration arrangement [Member]
USD ($)
Sep. 30, 2014
Teva Pharmaceutical Industries Ltd. [Member]
Collaboration arrangement [Member]
USD ($)
Other Commitments [Line Items]                          
Collaboration agreement aggregate amount                       $ 50,000,000  
Maximum amount receivable                       370,000,000  
Equity investment 24,000,000                       10,000,000
Direct and indirect costs incurred                         30,000,000
Milestone payments                   1,600,000 7,750,000    
Amount receivable by Isis from TEVA as a milestone payment                     30.00%    
Percentage of un-spent portion to be paid                     30.00%    
Obligation to pay patent costs and annual license maintenance fees                   8,000      
Milestone payment                   100,000 800,000    
Expiry period of agreement of patented license                     20 years    
Range of each product line                     10 years    
Milestone payment due                 20,000,000   20,000,000    
Period of milestone payment                 21 days   21 days    
Reserve for contingency of non payment of non-royalty milestone amount                 20,000,000   20,000,000    
Milestone payment made                 10,000,000   10,000,000    
Balance amount of milestone payment                 10,000,000   10,000,000    
Expiration of operating lease agreement       2015-09                  
Expiration of non-cancellable operating lease agreement       2017                  
Cash security deposit               500,000          
Standby letter of credit   300,000   300,000                  
Lease liability           3,324,000 3,906,000            
Consolidated rent and facilities expense   700,000 700,000 2,100,000 2,100,000                
Indemnification obligations   0   0                  
Expenses related to indemnification issues   $ 0   $ 0