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Commitments and Contingencies - Additional Information (Detail)
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3 Months Ended | 9 Months Ended | 1 Months Ended | 9 Months Ended | 9 Months Ended | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Sep. 30, 2013
USD ($)
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Sep. 30, 2012
USD ($)
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Sep. 30, 2013
USD ($)
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Sep. 30, 2012
USD ($)
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Sep. 30, 2013
Excess Lease Facility [Member]
USD ($)
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Dec. 31, 2012
Excess Lease Facility [Member]
USD ($)
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Sep. 30, 2013
Other Assets [Member]
USD ($)
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Dec. 31, 2009
Teva Pharmaceutical Industries Ltd. [Member]
Collaborative Arrangement [Member]
USD ($)
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Sep. 30, 2013
Teva Pharmaceutical Industries Ltd. [Member]
Collaborative Arrangement [Member]
USD ($)
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Dec. 31, 2012
Teva Pharmaceutical Industries Ltd. [Member]
Collaborative Arrangement [Member]
USD ($)
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Sep. 30, 2013
University of British Columbia [Member]
Collaborative Arrangement [Member]
CAD
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Sep. 30, 2013
Isis Pharmaceuticals Inc. [Member]
Collaborative Arrangement [Member]
USD ($)
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| Other Commitments [Line Items] | ||||||||||||
| Collaboration Agreement aggregate amount | $ 50,000,000 | |||||||||||
| Maximum amount receivable | 370,000,000 | |||||||||||
| Equity investment | 53,777,000 | 10,000,000 | 10,000,000 | |||||||||
| Required contribution for direct and indirect development costs | 30,000,000 | |||||||||||
| Direct and indirect costs incurred | 30,000,000 | |||||||||||
| Milestone payments | 1,600,000 | 7,750,000 | ||||||||||
| Amount receivable by Isis from TEVA as a milestone payment | 30.00% | |||||||||||
| Percentage of un-spent portion to be paid | 30.00% | |||||||||||
| Obligation to pay patent costs and license maintenance fees | 8,000 | |||||||||||
| Milestone payment | 100,000 | 800,000 | ||||||||||
| Expiry period of agreement of patented license | 20 years | |||||||||||
| Range of each product line | 10 years | |||||||||||
| Milestone payment due | 20,000,000 | |||||||||||
| Period of milestone payment | 21 days | |||||||||||
| Reserve for contingency of non payment of non-royalty milestone amount | 20,000,000 | |||||||||||
| Milestone payment made | 10,000,000 | |||||||||||
| Balance amount of milestone payment | 10,000,000 | |||||||||||
| Expiration of operating lease agreement | 2014-09 | |||||||||||
| Expiration of non-cancellable operating lease agreement | 2017 | |||||||||||
| Cash security deposit | 500,000 | |||||||||||
| Letter of credit | 300,000 | 300,000 | ||||||||||
| Lease liability | 4,082,000 | 4,586,000 | ||||||||||
| Consolidated rent expense | $ 700,000 | $ 700,000 | $ 2,100,000 | $ 2,000,000 | ||||||||