Common Stock (Tables)
|
12 Months Ended |
Dec. 31, 2012
|
Common Stock [Abstract] |
|
Summary of fair value option award |
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
2012 |
|
|
2011 |
|
|
2010 |
|
Risk-free interest rates
|
|
|
0.96 |
% |
|
|
1.70 |
% |
|
|
2.73 |
% |
Expected dividend yield
|
|
|
0 |
% |
|
|
0 |
% |
|
|
0 |
% |
Expected life
|
|
|
5.9 years |
|
|
|
5.9 years |
|
|
|
6.8 years |
|
Expected volatility
|
|
|
95 |
% |
|
|
76 |
% |
|
|
75 |
% |
|
Summary of share-based compensation expense |
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|
|
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|
|
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|
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|
Years ended December 31, |
|
|
|
2012 |
|
|
2011 |
|
|
2010 |
|
|
|
$ |
|
|
$ |
|
|
$ |
|
Research and development
|
|
|
899 |
|
|
|
509 |
|
|
|
331 |
|
General and administrative
|
|
|
1,276 |
|
|
|
679 |
|
|
|
311 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total stock-based compensation
|
|
|
2,175 |
|
|
|
1,188 |
|
|
|
642 |
|
|
Summary of stock options activity |
|
|
|
|
|
|
|
|
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|
Number of Optioned Common Shares |
|
|
Weighted Average Exercise Price |
|
|
|
# |
|
|
$ |
|
Balance, December 31, 2009
|
|
|
802,871 |
|
|
|
6.95 |
|
Option grants
|
|
|
170,872 |
|
|
|
15.87 |
|
Option cancellations
|
|
|
(7,311 |
) |
|
|
104.91 |
|
Option exercises
|
|
|
(194,956 |
) |
|
|
4.22 |
|
|
|
|
|
|
|
|
|
|
Option forfeited
|
|
|
(26,563 |
) |
|
|
7.35 |
|
|
|
|
|
|
|
|
|
|
Balance, December 31, 2010
|
|
|
744,913 |
|
|
|
8.74 |
|
Option grants
|
|
|
101,600 |
|
|
|
15.72 |
|
Option cancellations
|
|
|
(22,986 |
) |
|
|
13.95 |
|
Option exercises
|
|
|
(56,228 |
) |
|
|
3.88 |
|
Option forfeited
|
|
|
(971 |
) |
|
|
41.91 |
|
|
|
|
|
|
|
|
|
|
Balance, December 31, 2011
|
|
|
766,328 |
|
|
|
9.82 |
|
Option grants
|
|
|
172,650 |
|
|
|
12.97 |
|
Option cancellations
|
|
|
(12,309 |
) |
|
|
9.10 |
|
Option exercises
|
|
|
(117,347 |
) |
|
|
3.94 |
|
Option forfeited
|
|
|
(4,541 |
) |
|
|
15.26 |
|
|
|
|
|
|
|
|
|
|
Balance, December 31, 2012
|
|
|
804,781 |
|
|
|
11.34 |
|
|
Summary of stock options outstanding regarding the number of ordinary shares issuable upon exercise of outstanding options |
Exercise Prices
|
|
Number of Options |
|
|
Weighted- Average Exercise
Price $
|
|
|
Weighted- Average Remaining Contractual Life
(in years)
|
|
$2.69 — $2.85
|
|
|
34,000 |
|
|
|
2.69 |
|
|
|
2.82 |
|
$2.86 — $3.56
|
|
|
232,600 |
|
|
|
3.00 |
|
|
|
2.98 |
|
$3.57 — $12.48
|
|
|
68,840 |
|
|
|
10.12 |
|
|
|
6.85 |
|
$12.49 — $12.81
|
|
|
22,000 |
|
|
|
12.56 |
|
|
|
9.46 |
|
$12.82 — $13.06
|
|
|
118,750 |
|
|
|
13.00 |
|
|
|
9.35 |
|
$13.07 — $15.74
|
|
|
43,176 |
|
|
|
14.26 |
|
|
|
8.46 |
|
$15.75 — $16.40
|
|
|
121,700 |
|
|
|
15.97 |
|
|
|
7.95 |
|
$16.41 — $17.67
|
|
|
48,500 |
|
|
|
16.92 |
|
|
|
8.14 |
|
$17.68 — $21.67
|
|
|
39,115 |
|
|
|
18.95 |
|
|
|
5.24 |
|
$21.68 — $22.28
|
|
|
76,100 |
|
|
|
22.28 |
|
|
|
6.90 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total
|
|
|
804,781 |
|
|
|
11.34 |
|
|
|
6.26 |
|
|
Summary of stock options outstanding regarding the number of ordinary shares issuable upon exercise of vested options |
Exercise Prices
|
|
Number of Options |
|
|
Weighted- Average Exercise
Price $
|
|
|
Weighted- Average Remaining Contractual Life
(in years)
|
|
$2.69 — $2.85
|
|
|
34,000 |
|
|
|
2.69 |
|
|
|
2.82 |
|
$2.86 — $3.56
|
|
|
232,600 |
|
|
|
3.00 |
|
|
|
2.98 |
|
$3.57 — $12.48
|
|
|
37,839 |
|
|
|
8.56 |
|
|
|
5.10 |
|
$12.49 — $12.81
|
|
|
42 |
|
|
|
12.61 |
|
|
|
9.91 |
|
$12.82 — $13.06
|
|
|
27,214 |
|
|
|
13.00 |
|
|
|
9.35 |
|
$13.23 — $15.74
|
|
|
20,111 |
|
|
|
14.48 |
|
|
|
7.75 |
|
$15.75 — $16.40
|
|
|
60,850 |
|
|
|
15.97 |
|
|
|
7.95 |
|
$16.41 — $17.67
|
|
|
21,906 |
|
|
|
16.91 |
|
|
|
8.12 |
|
$17.68 — $21.67
|
|
|
38,327 |
|
|
|
18.90 |
|
|
|
5.26 |
|
$21.68 — $22.28
|
|
|
57,076 |
|
|
|
22.28 |
|
|
|
6.90 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total
|
|
|
529,965 |
|
|
|
9.62 |
|
|
|
5.00 |
|
|
Summary of restricted stock award activity |
|
|
|
|
|
|
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|
|
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|
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|
2012 |
|
|
2011 |
|
|
|
Stock Awards #
|
|
|
Weighted- Average Grant Date Fair
Value $
|
|
|
Stock Awards #
|
|
|
Weighted- Average Grant
Date Fair Value $
|
|
Outstanding January 1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
Granted
|
|
|
180,085 |
|
|
|
13.01 |
|
|
|
— |
|
|
|
— |
|
Vested
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
Forfeited and expired
|
|
|
(8,000 |
) |
|
|
13.00 |
|
|
|
— |
|
|
|
— |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Outstanding December 31
|
|
|
172,085 |
|
|
|
13.01 |
|
|
|
— |
|
|
|
— |
|
|
Summary of fair value of warrants issued |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Years ended December 31, |
|
|
|
2012 |
|
|
2011 |
|
|
2010 |
|
Risk-free interest rates
|
|
|
0.34 |
% |
|
|
0.55 |
% |
|
|
2.01 |
% |
Expected dividend yield
|
|
|
0 |
% |
|
|
0 |
% |
|
|
0 |
% |
Expected life
|
|
|
2.8 years |
|
|
|
3.8 years |
|
|
|
4.8 years |
|
Expected volatility
|
|
|
45 |
% |
|
|
76 |
% |
|
|
75 |
% |
|
Computation of basic and diluted net loss attributable to common shareholders per share |
|
|
|
|
|
|
|
|
|
|
|
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|
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|
Years ended December 31, |
|
(in thousands except shares and per share amounts)
|
|
2012 |
|
|
2011 |
|
|
2010 |
|
|
|
|
|
Numerator
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net loss attributable to common shareholders
|
|
$ |
21,099 |
|
|
$ |
14,673 |
|
|
$ |
12,584 |
|
|
|
|
|
Denominator
|
|
|
|
|
|
|
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|
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|
Weighted average number of common shares outstanding
|
|
|
13,522,723 |
|
|
|
9,729,340 |
|
|
|
7,030,903 |
|
|
|
|
|
Basic and diluted net loss per common share
|
|
$ |
1.56 |
|
|
$ |
1.51 |
|
|
$ |
1.79 |
|
|