Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Detail)

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Commitments and Contingencies - Additional Information (Detail)
1 Months Ended 3 Months Ended 4 Months Ended
Aug. 01, 2015
ft²
Apr. 24, 2015
USD ($)
Aug. 31, 2016
USD ($)
Feb. 28, 2015
USD ($)
ft²
Mar. 31, 2017
USD ($)
Mar. 31, 2016
USD ($)
Apr. 24, 2015
USD ($)
Mar. 31, 2017
CAD
May 14, 2015
Feb. 01, 2015
USD ($)
Other Commitments [Line Items]                    
Expiration of operating lease agreement         2016-09          
Additional office space | ft² 2,245                  
Consolidated rent and facilities expense         $ 100,000 $ 100,000        
Lease termination agreement, additional fee payable       $ 1,300,000            
Indemnification obligations         0          
Expenses related to indemnification issues         0          
Vancouver, Canada [Member]                    
Other Commitments [Line Items]                    
Aggregate future minimum annual lease payments under the lease         46,000,000          
Ionis Pharmaceuticals Inc. [Member]                    
Other Commitments [Line Items]                    
Litigation settlement, upfront payment     $ 1,400,000              
Royalty payment percentage     5.00%              
Sale, license or other transaction payment percentage     50.00%              
Ionis Pharmaceuticals Inc. [Member] | Maximum [Member]                    
Other Commitments [Line Items]                    
Litigation settlement, success based payment     $ 5,000,000              
Grosvenor International Limited [Member]                    
Other Commitments [Line Items]                    
Area of office space leased | ft²       11,526            
Expiration date of option to lease additional area of office space       Aug. 01, 2015            
Lease expiration date       Apr. 30, 2018            
Optional lease renewal       3 years            
Monthly base rent commencement date       May 01, 2015            
Lessee's share of property tax percentage.       17.00%            
Construction allowance received for leasehold improvements                   $ 100,000
Deposit amount under lease agreement                   $ 200,000
Grosvenor International Limited [Member] | Maximum [Member]                    
Other Commitments [Line Items]                    
Monthly base rent       $ 20,000            
Grosvenor International Limited [Member] | Minimum [Member]                    
Other Commitments [Line Items]                    
Monthly base rent       $ 18,000            
BMR-217TH Place LLC [Member]                    
Other Commitments [Line Items]                    
Lease termination agreement, date of termination       Mar. 01, 2015            
Letter of credit drawn to pay deferred state sales tax       $ 100,000            
Letter of credit terminated       200,000            
Terminated lease       500,000            
BMR-217TH Place LLC [Member] | Termination Fee [Member]                    
Other Commitments [Line Items]                    
Lease termination agreement, fee payable       2,000,000            
BMR-217TH Place LLC [Member] | Minimum [Member]                    
Other Commitments [Line Items]                    
Amount of funding to raise that would trigger payment of additional termination fee       $ 20,000,000            
Collaborative Arrangement [Member] | Teva Pharmaceutical Industries Ltd. [Member]                    
Other Commitments [Line Items]                    
Proceeds from advance reimbursement research and development             $ 27,000,000      
Hold-back amount and third-party expenses deducted from advanced reimbursement payment   $ 3,800,000         3,800,000      
Hold-back amount deducted from advanced reimbursement payment   3,000,000         3,000,000      
Third-party expenses deducted from advanced reimbursement payment             $ 800,000      
Maximum cost exposure if third-party agreements discovered after the termination date         $ 100,000          
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member]                    
Other Commitments [Line Items]                    
Collaboration agreement aggregate amount   $ 23,200,000                
Hold-back amount, requested payment percentage                 30.00%  
Lawsuit filing date         January 2016          
Range of each product line         10 years          
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member] | Maximum [Member]                    
Other Commitments [Line Items]                    
Milestone payments         $ 4,300,000          
Collaborative Arrangement [Member] | University of British Columbia [Member] | Maximum [Member]                    
Other Commitments [Line Items]                    
Milestone payments | CAD               CAD 800,000    
Payments for royalty         $ 0