QuickLinks -- Click here to rapidly navigate through this document


Exhibit 32.2

Certification Pursuant to Rule 13a-14(b) or Rule 15d-14(b) of the Securities Exchange Act of 1934 and U.S.C. Section 1350

        I, Alan Fuhrman, Senior Vice President and Chief Financial Officer of Sonus Pharmaceuticals, Inc. (the "Company"), certify, pursuant to Rule 13a-14(b) or Rule 15d-14(b) of the Securities Exchange Act of 1934 and 18 U.S.C. Section 1350, that:

    /s/  ALAN FUHRMAN      
Alan Fuhrman
Senior Vice President and Chief Financial Officer



QuickLinks