Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies - Additional Information (Detail)

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Commitments and Contingencies - Additional Information (Detail)
 1 Months Ended 4 Months Ended 12 Months Ended
Aug. 01, 2015
ft²
Apr. 24, 2015
USD ($)
Feb. 28, 2015
USD ($)
ft²
Dec. 31, 2009
USD ($)
Apr. 24, 2015
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Dec. 31, 2015
CAD
May. 14, 2015
Feb. 01, 2015
USD ($)
Other Commitments [Line Items]                      
Gross Proceeds             $ 22,372,000        
Expiration of operating lease agreement           2016-09          
Additional office space | ft² 2,245                    
Consolidated rent and facilities expense           $ 900,000 2,800,000 $ 2,800,000      
Lease termination agreement, additional fee payable     $ 1,300,000                
Lease termination liability           1,250,000 $ 3,250,000        
Indemnification obligations           0          
Expenses related to indemnification issues           0          
CANADA                      
Other Commitments [Line Items]                      
Future minimum annual lease payments under the Vancouver lease           62,000,000          
Grosvenor International Limited [Member]                      
Other Commitments [Line Items]                      
Area of office space leased | ft²     11,526                
Additional area of office space available to lease, optional | ft²     8,054                
Expiration date of option to lease additional area of office space     Aug. 01, 2015                
Lease expiration date     Apr. 30, 2018                
Optional lease renewal     3 years                
Monthly base rent commencement date     May 01, 2015                
Lessee's share of property tax percentage.     17.00%                
Lease agreement, construction allowance receivable                     $ 100,000
Deposit amount under lease agreement                     $ 200,000
Grosvenor International Limited [Member] | Maximum [Member]                      
Other Commitments [Line Items]                      
Monthly base rent     $ 20,000                
Grosvenor International Limited [Member] | Minimum [Member]                      
Other Commitments [Line Items]                      
Monthly base rent     $ 18,000                
BMR-217TH Place LLC [Member]                      
Other Commitments [Line Items]                      
Lease termination agreement, date of termination     Mar. 01, 2015                
Letter of credit drawn to pay deferred state sales tax     $ 100,000                
Letter of credit terminated     200,000                
Terminated lease     500,000                
Lease termination liability           1,300,000          
BMR-217TH Place LLC [Member] | Termination Fee [Member]                      
Other Commitments [Line Items]                      
Lease termination agreement, fee payable     2,000,000                
BMR-217TH Place LLC [Member] | Minimum [Member]                      
Other Commitments [Line Items]                      
Amount of funding to raise that would trigger payment of additional termination fee     $ 20,000,000                
Collaborative Arrangement [Member] | Teva Pharmaceutical Industries Ltd. [Member]                      
Other Commitments [Line Items]                      
Proceeds from advance reimbursement research and development         $ 27,000,000            
Hold-back amount and third-party expenses deducted from advanced reimbursement payment   $ 3,800,000     3,800,000            
Hold-back amount deducted from advanced reimbursement payment   3,000,000     3,000,000            
Third-party expenses deducted from advanced reimbursement payment         $ 800,000            
Maximum cost exposure if third-party agreements discovered after the termination date           100,000          
Collaboration agreement aggregate amount       $ 50,000,000              
Gross Proceeds           10,000,000          
Direct and indirect costs incurred           $ 30,000,000          
Collaborative Arrangement [Member] | University of British Columbia [Member] | Maximum [Member]                      
Other Commitments [Line Items]                      
Milestone payments | CAD                 CAD 1,600,000    
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member]                      
Other Commitments [Line Items]                      
Collaboration agreement aggregate amount   $ 23,200,000                  
Net proceed from collaboration agreement amount, requested payment percentage                   20.00%  
Hold-back amount, requested payment percentage                   30.00%  
Lawsuit filing date           January 5, 2016          
Amount due to Ionis for reimbursement for research and development activities           $ 0          
Range of each product line           10 years          
Milestone payment due           $ 20,000,000          
Period of milestone payment           21 days          
Reserve for contingency of non payment of non-royalty milestone amount           $ 20,000,000          
Milestone payment made           10,000,000          
Balance amount of milestone payment           10,000,000          
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member] | Maximum [Member]                      
Other Commitments [Line Items]                      
Milestone payments           7,750,000          
Damages arise due to termination of agreement           $ 10,000,000