Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Detail)

v3.5.0.2
Commitments and Contingencies - Additional Information (Detail)
1 Months Ended 3 Months Ended 4 Months Ended 9 Months Ended
Aug. 01, 2015
ft²
Apr. 24, 2015
USD ($)
Aug. 31, 2016
USD ($)
Feb. 29, 2016
USD ($)
Employee
Feb. 28, 2015
USD ($)
ft²
Dec. 31, 2009
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2015
USD ($)
Apr. 24, 2015
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2016
CAD
Jun. 30, 2016
USD ($)
Dec. 31, 2015
USD ($)
May 14, 2015
Feb. 01, 2015
USD ($)
Other Commitments [Line Items]                                
Expiration of operating lease agreement                   2017-09            
Additional office space | ft² 2,245                              
Consolidated rent and facilities expense             $ 100,000 $ 100,000   $ 400,000 $ 800,000          
Lease termination agreement, additional fee payable         $ 1,300,000                      
Lease termination liability                           $ 1,250,000    
Indemnification obligations             0     0            
Expenses related to indemnification issues                   0            
Reduction in workforce | Employee       11                        
Percentage of workforce reduction       27.00%                        
Expenses on workforce reduction       $ 400,000                        
Vancouver, Canada [Member]                                
Other Commitments [Line Items]                                
Aggregate future minimum annual lease payments under the lease             100,000     100,000            
Ionis Pharmaceuticals Inc. [Member]                                
Other Commitments [Line Items]                                
Litigation settlement, upfront payment     $ 1,400,000                          
Royalty payment percentage     5.00%                          
Sale, license or other transaction payment percentage     50.00%                          
Ionis Pharmaceuticals Inc. [Member] | Maximum [Member]                                
Other Commitments [Line Items]                                
Litigation settlement, success based payment     $ 5,000,000                          
Grosvenor International Limited [Member]                                
Other Commitments [Line Items]                                
Area of office space leased | ft²         11,526                      
Expiration date of option to lease additional area of office space         Aug. 01, 2015                      
Lease expiration date         Apr. 30, 2018                      
Optional lease renewal         3 years                      
Monthly base rent commencement date         May 01, 2015                      
Lessee's share of property tax percentage.         17.00%                      
Construction allowance received for leasehold improvements                               $ 100,000
Deposit amount under lease agreement                               $ 200,000
Grosvenor International Limited [Member] | Maximum [Member]                                
Other Commitments [Line Items]                                
Monthly base rent         $ 20,000                      
Grosvenor International Limited [Member] | Minimum [Member]                                
Other Commitments [Line Items]                                
Monthly base rent         $ 18,000                      
BMR-217TH Place LLC [Member]                                
Other Commitments [Line Items]                                
Lease termination agreement, date of termination         Mar. 01, 2015                      
Letter of credit drawn to pay deferred state sales tax         $ 100,000                      
Letter of credit terminated         200,000                      
Terminated lease         500,000                      
Lease termination liability                         $ 1,300,000      
Reversed lease termination liability current             1,300,000     1,300,000            
BMR-217TH Place LLC [Member] | Termination Fee [Member]                                
Other Commitments [Line Items]                                
Lease termination agreement, fee payable         2,000,000                      
BMR-217TH Place LLC [Member] | Minimum [Member]                                
Other Commitments [Line Items]                                
Amount of funding to raise that would trigger payment of additional termination fee         $ 20,000,000                      
Collaborative Arrangement [Member] | Teva Pharmaceutical Industries Ltd. [Member]                                
Other Commitments [Line Items]                                
Proceeds from advance reimbursement research and development                 $ 27,000,000              
Hold-back amount and third-party expenses deducted from advanced reimbursement payment   $ 3,800,000             3,800,000              
Hold-back amount deducted from advanced reimbursement payment   3,000,000             3,000,000              
Third-party expenses deducted from advanced reimbursement payment                 $ 800,000              
Maximum cost exposure if third-party agreements discovered after the termination date                   100,000            
Collaboration agreement aggregate amount           $ 50,000,000                    
Gross proceeds                   10,000,000            
Direct and indirect costs incurred             30,000,000     $ 30,000,000            
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member]                                
Other Commitments [Line Items]                                
Collaboration agreement aggregate amount   $ 23,200,000                            
Net proceed from collaboration agreement amount, requested payment percentage                             20.00%  
Hold-back amount, requested payment percentage                             30.00%  
Lawsuit filing date                   January 2016            
Range of each product line                   10 years            
Collaborative Arrangement [Member] | Ionis Pharmaceuticals Inc. [Member] | Maximum [Member]                                
Other Commitments [Line Items]                                
Milestone payments             $ 7,750,000     $ 7,750,000            
Collaborative Arrangement [Member] | University of British Columbia [Member] | Maximum [Member]                                
Other Commitments [Line Items]                                
Milestone payments | CAD                       CAD 1,600,000