FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
JACOBS CINDY
   2. Issuer Name and Ticker or Trading Symbol
ACHIEVE LIFE SCIENCES, INC. [ACHV] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
EVP, CMO
(Last)
(First)
(Middle)
19820 NORTH CREEK PARKWAY, SUITE 201		 3. Date of Earliest Transaction (Month/Day/Year)
08/01/2017
(Street)

BOTHELL, WA 98011		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock               7,975 (1) D  

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Restricted Stock Unit (RSU) (2) 08/01/2017   A   54,800     (3) 08/01/2021(4) Common Stock 54,800 $ 0 54,800 D  
Stock Option (right to buy) $ 4.57 08/01/2017   A   274,000     (5) 08/01/2027 Common Stock 274,000 $ 0 274,000 D  
Stock Option (right to buy) $ 245.08 (1)               (6) 12/31/2019 Common Stock 1,090 (1)   1,090 D  
Stock Option (right to buy) $ 175.67 (1)               (6) 12/14/2020 Common Stock 1,818 (1)   1,818 D  
Stock Option (right to buy) $ 143 (1)               (6) 05/08/2022 Common Stock 1,363 (1)   1,363 D  
Stock Option (right to buy) $ 131.45 (1)               (6) 03/12/2023 Common Stock 1,818 (1)   1,818 D  
Stock Option (right to buy) $ 129.69 (1)               (7) 03/14/2024 Common Stock 2,272 (1)   2,272 D  
Stock Option (right to buy) $ 20.46 (1)               (8) 05/19/2025 Common Stock 3,409 (1)   3,409 D  
Restricted Stock Unit (RSU) (2)               (9) 04/01/2018 Common Stock 284 (1)   284 D  
Restricted Stock Unit (RSU) (2)               (10) 06/12/2018 Common Stock 454 (1)   454 D  
Restricted Stock Unit (RSU) (2)               (11) 05/19/2019 Common Stock 852 (1)   852 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
JACOBS CINDY
19820 NORTH CREEK PARKWAY, SUITE 201
BOTHELL, WA 98011		       EVP, CMO  

Signatures

 Sandra Thomson as attorney-in-fact for Cindy Jacobs   08/03/2017
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Reflects the 11-for-1 reverse stock split effected on August 1, 2017 immediately following the merger between OncoGenex Pharmaceuticals, Inc. and Achieve Life Science, Inc.
(2) Each RSU represents a contingent right to receive one share of the issuer's common stock at settlement.
(3) Pursuant to the terms of the RSU, 25% of the total shares underlying the RSU vest annually on the later of (i) each anniversary of August 1, 2017 and (ii) the first day thereafter during which the issuer's trading window is open.
(4) The RSUs expire 30 days from the date they vest.
(5) The options vest as to 25% on August 1, 2018 and thereafter in monthly installments over 36 months.
(6) The options are fully vested and exercisable.
(7) The options vest in monthly installments over 48 months commencing one month from January 1, 2014.
(8) The options vest in monthly installments over 48 months commencing one month from January 1, 2015.
(9) Pursuant to the terms of the RSU, 25% of the total shares underlying the RSU vest annually on the later of (i) each anniversary of January 1, 2014 and (ii) the first day thereafter during which the issuer's trading window is open.
(10) Pursuant to the terms of the RSU, 25% of the total shares underlying the RSU vest annually on the later of (i) each anniversary of June 12, 2014 and (ii) the first day thereafter during which the issuer's trading window is open.
(11) Pursuant to the terms of the RSU, 25% of the total shares underlying the RSU vest annually on the later of (i) each anniversary of January 1, 2015 and (ii) the first day thereafter during which the issuer's trading window is open.

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